This appears to be an untitled work by the artist Sarah S. Stilwell (1878 - 1939). Stilwell was a student of illustration great Howard Pyle and was influenced by him as many of his students were, including N.C. Wyeth. Stilwell is known primarily as an illustrator of children, but this powerful image certainly shows her mastery of other subjects. There's not much bio information online about Stilwell, the little I could find is here at this link.
What do I love about this painting? Well, the style, of course. The devil may care attitude. The whole idea of this woman being in complete command of her situation. Nothing can daunt her, not even a growling leopard. What will happen ten minutes from now no one knows. But for the moment, she is the master of two dangerous animals - one who seems to be indulging her and another who may be having second thoughts.